Lofgren's Syndrome- a quick overview

Lofgren’s Syndrome is characterized by the triad of:

• Acute polyarthritis
•  Erythema nodosum
• Hilar adenopathy

This condition is generally self-limiting, however, certain features persist for some time. The polyarthritis and arthralgias may persist for up to 2 years and these symptoms may reoccur. The erythema nodosum typically resolves in a few months and the hilar adenopathy generally resolves over time. Note that parenchymal infiltrates and fever may be present.

In terms of investigations, approximately 15% of patients with this syndrome have elevation of their ACE serum levels. 

Interesting Article: 

Johan Grunewald and Anders Eklund "Löfgren's Syndrome", American Journal of Respiratory and Critical Care Medicine, Vol. 179, No. 4 (2009), pp. 307-312.

Lofgren's Syndrome: Human Leukocyte Antigen Strongly Influences the Disease Course